It is now recognized that the INTEGRATED TEST, which combines the two best first trimester markers (PAPP-A and NT measurement) with the second trimester Quad test (AFP, estriol (uE3), βHCG and Inhibin-A) will yield a superior detection rate of 94% for Down syndrome, with a 4% screen positive rate. This results in the need for fewer invasive diagnostic tests.

For patients requiring early testing, Combined results are available in the first trimester allowing for earlier diagnostic procedures such as chorionic villus sampling (CVS), while the QUAD test is appropriate for patients who present later in pregnancy. Ultrasound examinations (nuchal translucency measurements) can provide additional data for evaluations of risk, and are utilized in the Combined test and the Integrated 190 Test. LENETIX^® is prepared to assist offices with NT training and accreditation procedures. This professional support ensures that their sonographers meet the standards set by the medical community.

The below page is an overview of the options available for screening .

Test Name Identifies Increased Risk for: Recommended Gestational Age Detection Rates Test Code AFP Open Neural Tube Defects 15 weeks 0 days - 22 weeks 0 days    608   Anencephaly   99%     Open Spina Bifida   79% - 85%   AFP+QUAD Screen (AFP, total bhCG, uE3, inhibin-A) Open Neural Tube Defects, Anencephaly, Open Spina Bifida 15 weeks 0 days - 22 weeks 0 days     The COMBINED Test (PAPP-A, total bhCG, NY measurement) Down syndrome, Trisomy 18 11 weeks 0 days - 13 weeks 6 days 85% 1414 Triple Screen (AFP, total bhCG, uE3) Open Neural Tube Defects, Down syndrome, Trisomy 18 15 weeks 0 days - 22 weeks 0 days 71% 1520 Quad Screen (AFP, total bhCG, uE3, inhibin-A) Open Neural Tube Defects, Down syndrome, Trisomy 18 15 weeks 0 days - 22 weeks 0 days 78% 3121 The Integrated Test NT Measurement Open Neural Tube Defects, Down syndrome, Trisomy 18 Stage 1: 11 weeks 0 days - 13 weeks 6 days Stage 2: 15 weeks - 22 weeks 95%   The Integrated 190 (PAPP-A NT Measurement) (AFP, total bhCG, uE3, inhibin-A) Open Neural Tube Defects, Down syndrome, Trisomy 18 Stage 1: 11 weeks 0 days - 13 weeks 6 days Stage 2: 15 weeks - 22 weeks 95% 3325 The Modified Sequential 30•190 (PAPP-A NT Measurement) (AFP, total bhCG, uE3, inhibin-A) Open Neural Tube Defects, Down syndrome, Trisomy 18 Stage 1: 11 weeks 0 days - 13 weeks 6 days Stage 2: 15 weeks - 22 weeks     The CONTINGENT 30•1500•190 (PAPP-A + NT Measurement) (AFP, total bhCG, uE3, inhibin-A) Open Neural Tube Defects, Down syndrome, Trisomy 18 Stage 1: 11 weeks 0 days - 13 weeks 6 days Stage 2: 15 weeks - 22 weeks     Other BioChemical Tests       Tay-Sachs (Enzyme) Carrier Status Non-pregnant preferable 99%  556 Pre-term Labor Tests       Fetal Fibronectin Preterm Labor risk As indicated --- 1052 Inhibin B Fertility/Menopause Day 3 of menstrual Cycle ---